Neobotanics Anti-Wrinkle Skin Rejuvenator #1 anti-wrinkle serum with peptides, stem cells and hyaluronic acid 30 ml
Rapid wrinkle reduction, anti-aging, collagen reactivation
Ingredients
How to use
Product information
The NEOBOTANICS® brand
NEOBOTANICS® was founded on the basis of long-term scientific research into natural bioactive substances under the leadership of Associate Professor Petr Kaštánek, Ph.D., in cooperation with prominent Czech scientific institutions and leading experts in the field of medicine.
From the very beginning, we have been building on the conviction that truly valuable skin care and sophisticated dietary supplements should grow from a deep understanding of nature, precise research and high demands on the quality of each ingredient used.
BIOCEN laboratories
Research, development and production take place under strictly controlled conditions in the laboratories of our company BIOCEN laboratories and our laboratories in the Science and Technology Park Dobříš Centre for Applied Research (CAVD), set in the unique environment of the Brdy forests.
It is here that scientific precision, technological advancement and inspiration from nature, which is fundamental to the philosophy of the NEOBOTANICS® brand, are intertwined.
Associate Professor Petr Kaštánek, Ph.D.,
The founder of the NEOBOTANICS® brand is a Czech scientist and biotechnologist specializing in the entire chain of research, development and utilization of natural bioactive substances.
Within the research projects he leads, new active ingredients for cosmetic use and new approaches to their formulation are developed.
He is the holder of a number of patents and awards, including the Visionary 2016 title.
More about Petr HERE.

View our Research Projects

In-house research and development
Our passion and expertise lie in developing high-quality products with well-thought-out compositions, offering sophisticated and functional skin care.
We emphasize careful selection of raw materials, balanced formulations, safety of use, and respect for sustainability and environmental protection. Each product is created with the aim of offering modern care that combines a scientific approach, attention to detail, and a high standard of quality.
At the heart of the company is the laboratory — a place where innovative ideas are born, new procedures are verified, and products are created that connect research, functionality, and a refined approach to modern care.
Combining modern science, research, and nature
We believe that the future of quality cosmetics and dietary supplements relies not only on the latest scientific knowledge but also on a sensitive connection to natural traditions.
Therefore, we return to our roots and rediscover the potential of traditional and lesser-known local herbs, plants, and other natural resources for use in dermatology, cosmetics, and nutrition.
These resources are explored through research projects led by the founder of the NEOBOTANICS® brand, biotechnologist and expert in natural active substances, doc. Ing. Petr Kaštánek, Ph.D. We extract valuable functional ingredients from them and verify their biological activity using modern analytical methods.
Bioactive, thoughtfully formulated ingredients
In many of our dietary supplements and cosmetic products, we use our own original and carefully prepared extracts.
Where appropriate for formulation, we work with bioactive substances in the form of liposomal or nano-micellar systems, prepared using our own NEOLIPO® and NEOMICELLE® processes.
These approaches allow us to design products with an emphasis on stability, quality, and a thoughtful use of active ingredients within the overall formulation.
Extreme origin, exceptional potential
In the development of dermo-cosmetic products, we also work with bioactive substances obtained from plants or microorganisms that naturally occur in extreme conditions.
It is precisely in such environments that these organisms create specific protective mechanisms and a natural spectrum of substances that help them cope with environmental stressors.
This unique natural origin is a valuable inspiration for us in creating products designed for modern, functional, and targeted skin care.
Double synergy
The philosophy of the NEOBOTANICS® brand, alongside scientific development inspired by natural bioactive substances, is also based on the principle of so-called double synergy.
The first level is the thoughtful combination of individual active ingredients within each product so that they together create a harmonious and functional whole.
The second level is the connection between external and internal care — that is, between dermo-cosmetics and carefully formulated dietary supplements within the broad NEOBOTANICS® portfolio.
It is precisely this comprehensive approach that characterizes our brand: science, nature, and thoughtful care in a refined, modern, and premium form.
Shipping Czech Republic:
- DPD Private (option to change date or address): 75 CZK
- Zásilkovna pick-up point or Z-box (selection after completing the order): 69.00 CZK
-
Zásilkovna home delivery (selection after completing the order): 99.00 CZK
FREE shipping for orders over 2,000 CZK (applies only to orders within the Czech Republic).
Payment options:
- Card online (instant transfer) free
- Bank transfer (transfer 1-2 days) free
- Cash on delivery (payment upon receipt): 30 CZK
Payment method providers: ComGate, Viva Payment
In case of cashless payment, the purchase price is due within 7 days from the conclusion of the purchase agreement.
Delivery time:
- within 2-3 business days for online card payment and cash on delivery
- within 2-4 business days for bank transfer payment
Questions regarding shipping and payment should be addressed to info@neobotanics.cz or by phone at +420 776 187 414
Shipping outside the Czech Republic:
Austria
AUS Home delivery HD (Orders 0kg–5kg): €10.00 /220 CZK
Belgium
France
Germany
DE Hermes HD (Orders 0kg–10kg): €8.00 /180 CZK
DE Home delivery HD (Orders 0kg–10kg): €9.00 /200 CZK
Hungary
HU Home delivery (Orders 0kg–5kg): Ft2,368.00 /170 CZK
Italy
IT Bartolini HD (Orders 0kg–5kg): €10.00 /220 CZK
IT HR Parcel HD(Orders 0kg–5kg): €10.00 /220 CZK
Poland
PL Home delivery HD (Orders 0kg–5kg): PLN 30.00 /170 CZK
PL Packeta Z-Point PP (Orders 0kg–5kg): PLN 30.00 /170 CZK
PT MRW HD (Orders 0kg–5kg): €10.00 /220 CZK
PT MRW PP (Orders 0kg–5kg): €10.00 /220 CZK
Slovakia
SK Packeta delivery HD (Orders 0kg–5kg): €6.00 /130 CZK
SK Packeta evening delivery HD (Orders 0kg–5kg): €7.00 /160 CZK
SK Z-Box Box (Orders 0kg–5kg): €4.00 /95 CZK
SK Zásilkovna * You select the Zásilkovna branch after completing the order (Orders 0kg–5kg): €4.00 /95 CZK
Payment options:
- Bank transfer (transfer 1-2 days) free
- Card online (instant transfer) free
- CAUTION: Cash on delivery is not possible for shipping outside the Czech Republic!
Delivery time:
- within 2-3 business days for card payment
- within 3-4 business days from the crediting of the amount to the account for bank transfer payment
Questions regarding shipping and payment should be addressed to info@neobotanics.cz or by phone at +420 776 187 414
Neobotanics Anti-Wrinkle Skin Rejuvenator #1 anti-wrinkle serum with peptides, stem cells and hyaluronic acid 30 ml
A complete revolution in skin care! Discover the power of science and nature.
Discover the innovative Beauty line from Neobotanics for perfect skin.
Magazine editorial tip
Marianne.cz editorial test: The best skin serums that will rejuvenate your skin in a few days, tested serum: Neobotanics Anti-Wrinkle Skin Rejuvenator #1 from the Neobotanics brand, founded by Czech biochemist Petr Kaštánek, belongs in the evening skin care routine. It is highly concentrated and has a fast and strong effect against wrinkles.
Editor's review (50 years old): It feels like a light liquid that you don't even know is there. You feel as if you only have a little water on your face. I was very pleasantly surprised that the results were visible right after waking up. The product increases skin hydration, firmness and elasticity, making the skin beautifully rejuvenated.
You can try the effects of our skin serums and their combinations in a convenient test set.
Discovery set skin serum 4x4.5 ml

FOUR UNIQUE SKIN SERUMS backed by research into natural bioactive substances.
Two water serums marked #1:
- ANTI-WRINKLE SKIN REJUVENATOR #1 blue serum Marianne magazine editorial tip
- SKIN PERFECTOR #1 yellow serum recommended by VOGUE Czechoslovakia 2024 magazine
Two oil serums marked #2:
Interviews about individual serums with Doc. Ing. Petr Kaštánek, Ph.D., who is the founder of the Neobotanics brand and developed these products together with his team, can be found below.
ANTI-WRINKLE SKIN REJUVENATOR #1
Polypeptide and liposomal serum with stem cells
Highly concentrated aqueous liposomal serum with a unique peptide "delivery system", plant stem cell extracts, hyaluronic acid with a very small size and plant antioxidants from navel, ball, gardenia and janiba for a very fast and strong anti-wrinkle effect.
Do you want perfectly hydrated, soft and firm skin? Do you want to get rid of wrinkles and don't want to undergo any procedures?
Bet on the right effective ingredients offered by the revolutionary blue serum ANTI-WRINKLE SKIN REJUVENATOR #1.
Effects of ANTI-WRINKLE SKIN REJUVENATOR #1 Serum:
▪ Visibly reduces wrinkles by up to 67% in 28 days
▪ Increases skin elasticity by up to 106% in 6 weeks
▪ Increases collagen production and skin firmness
▪ Brightens
▪ Increases hydration
▪ Restores the skin microbiome
▪ Contains 5 biotechnological peptides
▪ stem cell extracts
▪ Liposomal active ingredients
▪ Very low molecular weight hyaluronic acid
Patented peptides eliminate wrinkles
The serum contains 5 specially selected and patented peptides that have undergone several studies, the percentages of the main results showed how much they contribute to the reduction of wrinkles per month of use. One of them showed up to 67% reduction of wrinkles in 28 days. This effectiveness is largely due to the special technology of the so-called cosmetic drone. One of the peptides used also gives the serum its characteristic blue color.
Beauty drone technology
This is a special "delivery system" that binds active ingredients (peptides) directly to the receptors of skin cells that are responsible for the production of collagen and collagen fibers. Thanks to the so-called "small drone", the active ingredients reach exactly the right place and thus their maximum use is achieved.
" This blue serum is unique in the combination and quantity of peptides and plant stem cell extracts used. It combines natural plant extracts and innovative biotechnological ingredients - e.g. deep sea microorganism ferment, stem cell extract, encapsulated peptides for complex anti-aging effects, etc. It is important that these bioactive substances used then activate the natural production of the skin's own molecules, such as collagen or the sirtuin enzyme. The effect is therefore more natural and long-lasting ," explains Doc. Ing. Petr Kaštánek, Ph.D. , scientist and director of research laboratories EcoFuel Laboratories and BIOCEN Laboratories, founder of the NEOBOTANICS cosmetic brands.
Based on research, extracts from lemon balm and heartwort stem cells were selected, which activate the natural defense mechanisms of skin cells and activate longevity enzymes that extend the lifespan of cells.
Special composition developed by Doc. Ing. Petr Kaštánek, Ph.D. , director of BIOCEN laboratories and founder of the NEOBOTANICS brand ™ , combines natural plant active ingredients and patented biotechnological innovative ingredients – 5 powerful anti-age peptides X50 Capsules ™ , Clodessin ™ , Argireline ™ Aplified, GCu11P ™ , NeoActine plant extracts ™ , stem cells by Resistem ™ and NeoCellTech ™ for comprehensive anti-aging effects, rapid wrinkle reduction and dramatically younger-looking skin.
The serum is quickly absorbed, does not leave a greasy layer on the skin and is designed to be combined with any skin care routine. It does not contain perfume or artificial colors.
Main active ingredients:
X50 Capsules ™ (Cu-Palmitoyl Heptapeptide-14, Heptapeptide-15 Palmitate peptides) – Encapsulated copper peptides using breakthrough technology targeting the active ingredient to specific receptors of skin cells – fibroblasts. Stimulates the synthesis of collagen and elastin at the gene expression level and significantly reduces wrinkles on the entire surface of the skin. Hydrates and nourishes the skin, leaving it silkier and more elastic, leaving it younger, smoother, brighter and firmer. The study [1] demonstrated a significant reduction in wrinkles on the entire surface of the skin. The reduction in wrinkle reduction was 33%, with the best responder achieving a 67% reduction in the surface of fine wrinkles, a 46% reduction in the number of wrinkles and a 59% reduction in the length of wrinkles.
Clodessin ™ (sh-Nonapeptide-4) – is an active fragment of the hormone Klotho, which protects against premature aging caused by daily stress, pollutants and free radicals and makes the skin healthier and smoother. It prolongs the life of cells and natural defense mechanisms in cells. Administration of the "youth hormone" Klotho to the skin cell has a truly rejuvenating effect. In 6 weeks of application, the depth of wrinkles was reduced by 52%, skin elasticity was increased by 106% and pores were reduced by 16%. [2]
Argireline ™ Aplified (Acetyl Hexapeptide-8) – Penetrates deep into the skin, reducing fine lines and wrinkles at their source and minimizing the aging process in all layers of the skin. A safer topical alternative to botulinum toxin, effective in just 1 week. Suppresses muscle contraction and relaxation of facial muscles. Less stiff facial muscles are more relaxed, which is associated with a youthful appearance and fewer facial wrinkles. In a study of improving the appearance of facial wrinkles, the area changed by 11% in just 5 days and the depth of wrinkles decreased by up to 46.7% in 28 days. [3]
GCu11P ™ (Copper Tripeptide-1) - Increases collagen production and improves the appearance of skin, giving it a biological appearance. In a study, it reduced wrinkles by 29%, wrinkle area by 29%, and increased skin elasticity by 21.6%. [4]
HyActiv ™ (active hydrolyzed hyaluronic acid of very low molecular weight) penetrates even into the lowest layers of the skin, where it stimulates the production of the body's own endogenous hyaluronic and collagen and has a rejuvenating effect - helps smooth the skin, reduces wrinkles and pores and hydrates the skin. It also acts as a prebiotic, restoring the skin microbiome after its disruption. Supports the skin microflora.
Resist ™ - plant extract from Globularia cordifolia stem cells helps the skin create its own anti-aging defense system. It supports detoxification, prolongs cell life by stimulating the enzyme sertuin-1 and tissue regeneration.
Genipa americana Extract – extract from the fruit of the South American genipa with antioxidant effects.
Gardenia Florida fruit extract – gardenia extract has antioxidant and anti-aging effects on the skin.
Globularia Alypum Leaf Extract – an extract from the Globularia Alypum Leaf to soothe irritated skin and slow down its aging. It supports the reduction of skin reactivity.
NeoActine ™ Centella - an extract from the Asian centella for skin care.
[1] Study on 30 volunteers aged 35-70, 2 applications per day for 28 days.
[2] Study of 31 women aged 34-57, applied to the skin for 6 weeks.
[3] Study of 41 women aged 34-60.
[4] Study of 32 women aged 25-55, twice daily application for 56 days
USE and APPLICATION Neobotanics Beauty skin serums
A) TESTING PHASE – individual testing of serums (without combinations):
1. Cleansing the skin (makeup removing oil/milk/foam)
2. Skin toning (toner)
3. SERUM – apply a few drops and let dry , 1-2 times a day, preferably in the morning and evening
4. Cream/skin oil
In the testing phase, we recommend trying each serum alone for 2-3 days, i.e. not combining it with other serums.
The serum can be applied 1-2 times a day, preferably in the morning and evening.
B) REGULAR APPLICATION – combination of serums:
1. Cleansing the skin (makeup removing oil/milk/foam)
2. Skin toning (toner)
3. SERUM #1 - apply a few drops of water-based serum (#1) and let dry
4. SERUM #2 - apply a few drops of oil serum (#2) and let dry
5. Cream/skin oil
Drying time: water-based serum (#1) approx. 10 seconds, oil-based serum (#2) a little longer, approx. 30-60 seconds.
With regular application, serums can be combined, namely any water-based (#1) and oil-based serum (#2) , according to the current needs of the skin, see serum combinations.
Drying time: water-based serum (#1) approx. 10 seconds , oil-based serum (#2) approx. 30-60 seconds .
Quantity: only a few drops are needed, the serums are very concentrated. We recommend 1 drop on each cheek, another on the chin, nose and forehead, i.e. a total of about 5 drops.
How often to apply: 1-2 times a day , always in the evening, preferably in the morning and evening.
Notice:
We do not recommend layering the same type of serum twice = do not apply two water-based serums (#1 and #1) or two oil-based serums (#2 and #2) on top of each other. That is why the bottles are marked #1 and #2.
Using two of the same types of serums at the same time could disrupt the synergistic effect of the active ingredients or cause skin irritation due to an unnecessarily high amount of active ingredients.
SERUM COMBINATION:
Dry skin, deep wrinkles, loss of brightness and elasticity:
ANTI-WRINKLE SKIN REJUVENATOR #1 + INSTANT BEAUTY & RADIANCE #2
Dry skin, wrinkles, hyperpigmentation:
ANTI-WRINKLE SKIN REJUVENATOR #1 + YOUTH BOOSTER #2
Problematic skin, enlarged pores, acne, uneven skin tone:
SKIN PERFECTOR #1 + INSTANT BEAUTY & RADIANCE #2
Damaged skin, wrinkles, dehydration, hyperpigmentation:
SKIN PERFECTOR #1 + YOUTH BOOSTER #2
Do you want to learn about Anti-Age bioactive peptides that can help with wrinkles on your skin?
More about the article Anti-Age Bioactive Peptides: A Revolution in the Fight Against Wrinkles on our blog HERE .
The NEOBOTANICS® brand
NEOBOTANICS® was founded on the basis of long-term scientific research into natural bioactive substances under the leadership of Associate Professor Petr Kaštánek, Ph.D., in cooperation with prominent Czech scientific institutions and leading experts in the field of medicine.
From the very beginning, we have been building on the conviction that truly valuable skin care and sophisticated dietary supplements should grow from a deep understanding of nature, precise research and high demands on the quality of each ingredient used.
BIOCEN laboratories
Research, development and production take place under strictly controlled conditions in the laboratories of our company BIOCEN laboratories and our laboratories in the Science and Technology Park Dobříš Centre for Applied Research (CAVD), set in the unique environment of the Brdy forests.
It is here that scientific precision, technological advancement and inspiration from nature, which is fundamental to the philosophy of the NEOBOTANICS® brand, are intertwined.
Associate Professor Petr Kaštánek, Ph.D.,
The founder of the NEOBOTANICS® brand is a Czech scientist and biotechnologist specializing in the entire chain of research, development and utilization of natural bioactive substances.
Within the research projects he leads, new active ingredients for cosmetic use and new approaches to their formulation are developed.
He is the holder of a number of patents and awards, including the Visionary 2016 title.
More about Petr HERE.

View our Research Projects

In-house research and development
Our passion and expertise lie in developing high-quality products with well-thought-out compositions, offering sophisticated and functional skin care.
We emphasize careful selection of raw materials, balanced formulations, safety of use, and respect for sustainability and environmental protection. Each product is created with the aim of offering modern care that combines a scientific approach, attention to detail, and a high standard of quality.
At the heart of the company is the laboratory — a place where innovative ideas are born, new procedures are verified, and products are created that connect research, functionality, and a refined approach to modern care.
Combining modern science, research, and nature
We believe that the future of quality cosmetics and dietary supplements relies not only on the latest scientific knowledge but also on a sensitive connection to natural traditions.
Therefore, we return to our roots and rediscover the potential of traditional and lesser-known local herbs, plants, and other natural resources for use in dermatology, cosmetics, and nutrition.
These resources are explored through research projects led by the founder of the NEOBOTANICS® brand, biotechnologist and expert in natural active substances, doc. Ing. Petr Kaštánek, Ph.D. We extract valuable functional ingredients from them and verify their biological activity using modern analytical methods.
Bioactive, thoughtfully formulated ingredients
In many of our dietary supplements and cosmetic products, we use our own original and carefully prepared extracts.
Where appropriate for formulation, we work with bioactive substances in the form of liposomal or nano-micellar systems, prepared using our own NEOLIPO® and NEOMICELLE® processes.
These approaches allow us to design products with an emphasis on stability, quality, and a thoughtful use of active ingredients within the overall formulation.
Extreme origin, exceptional potential
In the development of dermo-cosmetic products, we also work with bioactive substances obtained from plants or microorganisms that naturally occur in extreme conditions.
It is precisely in such environments that these organisms create specific protective mechanisms and a natural spectrum of substances that help them cope with environmental stressors.
This unique natural origin is a valuable inspiration for us in creating products designed for modern, functional, and targeted skin care.
Double synergy
The philosophy of the NEOBOTANICS® brand, alongside scientific development inspired by natural bioactive substances, is also based on the principle of so-called double synergy.
The first level is the thoughtful combination of individual active ingredients within each product so that they together create a harmonious and functional whole.
The second level is the connection between external and internal care — that is, between dermo-cosmetics and carefully formulated dietary supplements within the broad NEOBOTANICS® portfolio.
It is precisely this comprehensive approach that characterizes our brand: science, nature, and thoughtful care in a refined, modern, and premium form.
Frequently asked questions
Our knowledge. Your inspiration.
Discover articles full of tips, news, and interesting facts about natural cosmetics and a healthy lifestyle.
Cholesterol under control: best diet and supplements
Cholesterol under control: the best diet and supplements Cholesterol is a natural component of the human body: it forms cell membranes it participates in the formation of hormones and bile...
Otoky nohou a lymfatický systém: jak podpořit lymfu přirozeně
Otoky nohou a lymfatický systém: jak podpořit lymfu přirozeně Otoky nohou patří mezi časté obtíže, které se mohou objevovat přechodně i dlouhodobě. Někdy přijdou po dni stráveném ve stoje, po...
What You May Not Know About Cellulite | Causes, Grades, and Care
Cellulite affects up to 90% of women. What causes it, what are its stages, and are there effective ways to prevent it or reduce its symptoms?